S. W. Ragsdale

This study shows HO-2 binds and buffers oxidized labile heme in HEK293 cells, regulating heme homeostasis by controlling bioavailability rather than degrading heme under non-stress conditions.

This paper identifies that methyl-SCoM and CoMSSCoB bind to Ni(I) in MCR via sulfonate groups, not sulfur, and proposes long-range electron transfer as the mechanism for methane synthesis and oxidation.

This paper uses 13C-ENDOR spectroscopy to show Acetyl-CoA Synthase binds two CO molecules in different modes, highlighting the role of an alcove in stabilizing the Ni(I)-CO intermediate.

This study shows that Rev-Erbβ functions as a CO/NO sensor by coupling gas binding to electron transfer, maintaining Fe3+ heme state for repressor activity and enabling redox changes upon gas binding.

This study identifies that heme absence at the catalytic site of HO2 triggers its lysosomal degradation, distinct from other HRM-containing proteins and HO1.

This study reports the kinetics of HgcAB-mediated mercury methylation at nanomolar concentrations, showing high oxygen sensitivity and Michaelis-Menten kinetics with specific KM and Vmax values.