Epithelial HO-1 regulates iron availability and promotes colonic tumorigenesis in a context-dependent manner
R. C. Callahan, J. C. Curry, G. Bhagavatula, A. W. Staley, R. E. M. Schaefer, F. Minhajuddin, L. Zhou, R. M. Neuhart, S. M. Atif, D. J. Orlicky, I. M. Cartwright, M. E. Gerich, C. A. Steiner, A. L. Theiss, C. H. T. Hall, , J. C. Onyiah
This study shows that epithelial HO-1 promotes colonic tumorigenesis in chronic inflammation by increasing iron availability and oxidative stress, while protecting against acute heme toxicity.
bioRxiv · Mar 6, 2024Cancer Biology