D. J. Orlicky

Antigen-driven CD8+ T cell clonal expansion is a prominent feature of MASH in humans and mice.

This study identifies antigen-driven CD8+ T cell clonal expansion in human and mouse MASH, showing their activation and functional differentiation in liver disease.

Epithelial HO-1 regulates iron availability and promotes colonic tumorigenesis in a context-dependent manner

This study shows that epithelial HO-1 promotes colonic tumorigenesis in chronic inflammation by increasing iron availability and oxidative stress, while protecting against acute heme toxicity.

Endocrine pancreas-specific Gclc gene deletion causes a severe diabetes phenotype

This study shows that deleting the Gclc gene in the endocrine pancreas of mice leads to severe diabetes due to oxidative stress and islet dysfunction.

Dietary fat promotes antibiotic-induced Clostridioides difficile mortality in mice

A high-fat/low-fiber Western diet increased mortality in antibiotic-induced C. difficile infection in mice compared to low-fat/low-fiber and chow diets, suggesting lower fat may prevent CDI.

Novel insights into the mode of action of 1,4-dioxane using a systems screening approach

This study investigates the toxic effects of 1,4-dioxane in mice using histopathology and multi-omics approaches, finding DNA damage counterbalanced by repair mechanisms with no systemic metabolic impact.

Expression and T cell Regulatory Action of the PD-1 Immune Checkpoint in the Ovary and Fallopian Tube

This study shows PD-1 and its ligands are expressed by ovarian and fallopian tube cells, with functional implications for T cell regulation and immune privilege in reproductive tissues.

Down syndrome fibroblasts exhibit diminished autophagic clearance and endosomal dysfunction after serum starvation

This study shows that Down syndrome fibroblasts have impaired autophagic clearance and endosomal dysfunction after serum starvation, suggesting these as potential early pathogenic mechanisms.