Murine gammaherpesvirus 68 ORF45 stimulates B2 retrotransposon and pre-tRNA activation in a manner dependent on mitogen-activated protein kinase (MAPK) signaling
This paper identifies MHV68 ORF45 as an activator of RNAPIII transcription through MAPK/ERK signaling, increasing Brf1 levels and inducing B2 retrotransposon and pre-tRNA transcription.
bioRxiv · Jul 9, 2022Microbiology