Author

A. Larochelle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. Araki· 3 shared C. Salisbury-Ruf· 2 shared N. Redekar· 2 shared P. Dagur· 2 shared Y. Li· 2 shared A. Krouse· 1 shared B. Afzali· 1 shared B. Fisk· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

D. Araki

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

cMPL-Based Purification and Depletion of Human Hematopoietic Stem Cells: Implications for Pre-Transplant Conditioning

D. Araki, S. Hong, N. Linde, B. Fisk, N. Redekar, C. Salisbury-Ruf, A. Krouse, T. Engels, J. Golomb, P. Dagur, D. M. Magnani, Z. Wang, A. Larochelle

This study explores using cMPL as a target to selectively deplete human hematopoietic stem cells, showing potential for safer pre-transplant conditioning.

bioRxiv · Feb 24, 2024 · PreprintCell Biology

Post-Transplant Administration of G-CSF Impedes Engraftment of Gene Edited Human Hematopoietic Stem Cells by Exacerbating the p53-Mediated DNA Damage Response

D. Araki, V. Chen, N. Redekar, C. Salisbury-Ruf, Y. Luo, P. Liu, Y. Li, R. Smith, P. Dagur, C. Combs, A. Larochelle

This study shows that post-transplant G-CSF administration impairs engraftment of CRISPR-edited HSPCs by worsening the p53 DNA damage response, but not unedited or lentiviral-transduced HSPCs.

bioRxiv · Jun 29, 2023Cell Biology

Modulation of WNT, Activin/Nodal and MAPK Signaling Pathways Increases Arterial Hemogenic Endothelium and Hematopoietic Stem/Progenitor Cell Formation During Human iPSC Differentiation

Y. Li, J. Ding, D. Araki, J. Zou, A. Larochelle

bioRxiv · Feb 21, 2023Cell Biology

Systematic Single Cell Pathway Analysis (SCPA) reveals novel pathways engaged during early T cell activation

J. A. Bibby, D. Agarwal, T. Freiwald, N. Kunz, N. S. Merle, E. E. West, A. Larochelle, F. Chinian, S. Mukherjee, B. Afzali, C. Kemper, N. R. Zhang

SCPA identifies novel pathways in early T cell activation using scRNA-seq data, revealing unexpected regulatory mechanisms like type I interferon and arachidonic acid metabolism.

bioRxiv · Feb 7, 2022Immunology