Author

B. Afzali

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2

Frequent Co-Authors

B. Yan· 4 shared M. Kazemian· 4 shared C. Kemper· 3 shared D. Chauss· 3 shared L. Wang· 3 shared T. Freiwald· 3 shared A. Laurence· 2 shared E. Nova-Lamperti· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersMicrobiology

B. Yan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A comprehensive single cell data analysis of in lymphoblastoid cells reveals the role of Super-enhancers in maintaining EBV latency

B. Yan, C. Wang, S. Chakravorty, Z. Zhang, S. D. Kadadi, Y. Zhuang, I. Sirit, Y. Hu, M. Jung, S. Sahoo, L. Wang, K. Shao, N. L. Anderson, J. L. Trujillo-Ochoa, X. Liu, , M. Kazemian

This study uses scRNA-seq to analyze EBV latency in lymphoblastoid cells, identifying two distinct clusters with different EBV gene expression and revealing the role of super-enhancers in maintaining latency.

bioRxiv · Aug 10, 2022Microbiology

Systematic Single Cell Pathway Analysis (SCPA) reveals novel pathways engaged during early T cell activation

J. A. Bibby, D. Agarwal, T. Freiwald, N. Kunz, N. S. Merle, E. E. West, A. Larochelle, F. Chinian, S. Mukherjee, B. Afzali, C. Kemper, N. R. Zhang

SCPA identifies novel pathways in early T cell activation using scRNA-seq data, revealing unexpected regulatory mechanisms like type I interferon and arachidonic acid metabolism.

bioRxiv · Feb 7, 2022Immunology

Host-virus chimeric events in SARS-CoV2 infected cells are infrequent and artifactual

B. Yan, S. Chakravorty, C. Mirabelli, L. Wang, J. L. Trujillo-Ochoa, D. Chauss, D. Kumar, M. S. Lionakis, M. R. Olson, C. E. Wobus, B. Afzali, M. Kazemian

This study investigates host-virus chimeric (HVC) events in SARS-CoV2 RNA-seq data and finds they are rare and likely artifacts, not evidence of viral integration.

bioRxiv · Feb 17, 2021Microbiology

An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19

R. McGregor, D. Chauss, T. Freiwald, B. Yan, L. Wang, E. Nova-Lamperti, Z. Zhang, H. Teague, E. West, J. Bibby, A. Kelly, A. Malik, A. Freeman, D. Schwartz, D. Portilla, , B. Afzali

This study identifies a Vitamin D-driven mechanism that suppresses excessive Th1 responses in COVID-19, suggesting potential therapeutic use of Vitamin D analogs.

bioRxiv · Jul 18, 2020 · PreprintImmunology

RNF144A shapes the hierarchy of cytokine signaling to provide protective immunity against influenza

B. Afzali, S. Kim, E. West, E. Nova-Lamperti, N. Cheru, H. Nagashima, B. Yan, T. Freiwald, N. Merle, D. Chauss, M.-J. Bijlmakers, G. Wietsman, Z.-X. Yu, D. Jankovic, S. Mitra, , S. John

RNF144A regulates cytokine signaling hierarchy in T cells to enhance anti-influenza immunity by promoting STAT5 activation and limiting MAPK signaling.

bioRxiv · Sep 26, 2019 · PreprintImmunology