Mitochondrial dysfunction in skeletal muscle of fukutin deficient mice is resistant to exercise- and AICAR-induced rescue
W. M. Southern, A. S. Nichenko, A. E. Qualls, K. Portman, A. Gidon, A. M. Beedle, J. A. Call
This study shows that fukutin deficiency in mice causes mitochondrial dysfunction and reduced muscle strength, which is not rescued by exercise or AICAR, but AICAR improves muscle recovery after injury.
bioRxiv · May 27, 2020Physiology