Reinterpretation of the localization of the ATP binding cassette transporter ABCG1 in insulin-secreting cells and insights regarding its trafficking and function
M. T. Harris, S. S. Hussain, C. M. Inouye, A. M. Castle, J. D. Castle
This study updates the localization of ABCG1 in pancreatic beta cells, showing it accumulates in the TGN, ERC, and cell surface but not insulin granules, and suggests it regulates cholesterol distribution and membrane trafficking beyond the TGN.
bioRxiv · May 21, 2018Cell Biology