Author

J. D. Castle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:Drosophila· 1 Organism:mouse· 1

Frequent Co-Authors

A. M. Castle· 1 shared B. A. Martinez· 1 shared C. M. Inouye· 1 shared M. L. Bland· 1 shared M. T. Harris· 1 shared N. Leitinger· 1 shared R. G. Hoyle· 1 shared S. S. Hussain· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperCell Biology

A. M. Castle

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2 papers

Recent·Most cited

Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis in an ER stress-dependent manner.

B. A. Martinez, S. Yeudall, R. G. Hoyle, J. D. Castle, N. Leitinger, M. L. Bland

This study shows that Toll signaling in Drosophila fat body shifts lipid metabolism from triglyceride storage to phospholipid synthesis, driven by ER stress and AMP production demands.

bioRxiv · Mar 1, 2020Physiology

Reinterpretation of the localization of the ATP binding cassette transporter ABCG1 in insulin-secreting cells and insights regarding its trafficking and function

M. T. Harris, S. S. Hussain, C. M. Inouye, A. M. Castle, J. D. Castle

This study updates the localization of ABCG1 in pancreatic beta cells, showing it accumulates in the TGN, ERC, and cell surface but not insulin granules, and suggests it regulates cholesterol distribution and membrane trafficking beyond the TGN.

bioRxiv · May 21, 2018Cell Biology