Structural modeling of the hERG potassium channel and associated drug interactions
J. Maly, A. M. Emigh, K. R. DeMarco, K. Furutani, J. T. Sack, C. E. Clancy, I. Vorobyov, V. Yarov-Yarovoy
This study uses Rosetta to model structural changes in hERG channels caused by mutations and drug interactions, revealing conformational shifts and binding mechanisms.
bioRxiv · Jul 8, 2021Biophysics