Author

K. Furutani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:electrophysiology· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

J. T. Sack· 3 shared C. E. Clancy· 2 shared A. M. Emigh· 1 shared I. Vorobyov· 1 shared I.-S. Chen· 1 shared J. Maly· 1 shared K. Handa· 1 shared K. R. DeMarco· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersPharmacology & Toxicology

J. T. Sack

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Author profile →

3 papers

Recent·Most cited

Facilitation by a hERG blocker is induced by pore opening and operates by pore reopening

K. Furutani, R. Kawano, M. Ichiwara, R. Adachi, C. E. Clancy, J. T. Sack, S. Kita

This study investigates how nifekalant, a hERG blocker, facilitates hERG channel activation through pore opening rather than voltage sensors.

bioRxiv · May 26, 2022 · PreprintPharmacology & Toxicology

Structural modeling of the hERG potassium channel and associated drug interactions

J. Maly, A. M. Emigh, K. R. DeMarco, K. Furutani, J. T. Sack, C. E. Clancy, I. Vorobyov, V. Yarov-Yarovoy

This study uses Rosetta to model structural changes in hERG channels caused by mutations and drug interactions, revealing conformational shifts and binding mechanisms.

bioRxiv · Jul 8, 2021Biophysics

Facilitation of hERG channels by blockers: a mechanism predicted to reduce lethal cardiac arrhythmias

K. Furutani, K. Tsumoto, I.-S. Chen, K. Handa, Y. Yamakawa, J. T. Sack, Y. Kurachi

This paper proposes that hERG channel facilitation by blockers can reduce lethal cardiac arrhythmias by preventing early afterdepolarizations during repolarization.

bioRxiv · Jun 8, 2018Pharmacology & Toxicology