Author

C. E. Clancy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Pharmacology & Toxicology· 2 Physiology· 2

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Research Focus:drug response / drug discovery· 6 Organism:human· 6 Approach:deep learning· 5 Approach:statistical model· 4 Assay:electrophysiology· 3 Assay:protein structure· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

I. Vorobyov· 5 shared V. Yarov-Yarovoy· 5 shared P.-C. Yang· 4 shared K. R. DeMarco· 3 shared C. Matsumoto· 2 shared J. T. Sack· 2 shared K. Furutani· 2 shared K. Ngo· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersBiophysics

I. Vorobyov

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Author profile →

9 papers

Recent·Most cited

Harnessing AlphaFold to reveal hERG channel conformational state secrets

K. Ngo, P.-C. Yang, V. Yarov-Yarovoy, C. E. Clancy, I. Vorobyov

This paper uses AlphaFold to predict discrete conformational states of hERG channels, revealing structural features and drug interactions that improve drug safety screening.

bioRxiv · Jan 27, 2024Biophysics

The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes

C. Matsumoto, S. C. O'Dwyer, D. Manning, G. Hernandez-Hernandez, P. Rhana, Z. Fong, D. Sato, C. E. Clancy, N. C. Vierra, J. S. Trimmer, L. F. Santana

This study shows that KV2.1 macro-clusters regulate sex-specific differences in CaV1.2 clustering and function in arterial myocytes by modulating phosphorylation at S590.

bioRxiv · Jun 27, 2023Physiology

A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

G. Hernandez Hernandez, S. C. O'Dwyer, C. Matsumoto, M. Tieu, Z. Fong, P.-C. Yang, T. J. Lewis, L. F. Santana, C. E. Clancy

The paper develops a computational model to predict sex-specific responses to calcium channel blockers in arterial smooth muscle, revealing differences in ion channel regulation between male and female myocytes.

bioRxiv · Jun 24, 2023Physiology

Elucidating Molecular Mechanisms of Protoxin-2 State-specific Binding to the Human NaV1.7 Channel

K. Ngo, D. L. Mateos, Y. Han, K. C. Rouen, S.-H. Ahn, H. Wulff, C. E. Clancy, V. Yarov-Yarovoy, I. Vorobyov

This study uses computational modeling to investigate how protoxin-2 binds to different states of the hNaV1.7 channel, identifying key residues and lipid interactions that contribute to its selectivity.

bioRxiv · Feb 27, 2023Biophysics

Facilitation by a hERG blocker is induced by pore opening and operates by pore reopening

K. Furutani, R. Kawano, M. Ichiwara, R. Adachi, C. E. Clancy, J. T. Sack, S. Kita

This study investigates how nifekalant, a hERG blocker, facilitates hERG channel activation through pore opening rather than voltage sensors.

bioRxiv · May 26, 2022 · PreprintPharmacology & Toxicology

Structural modeling of the hERG potassium channel and associated drug interactions

J. Maly, A. M. Emigh, K. R. DeMarco, K. Furutani, J. T. Sack, C. E. Clancy, I. Vorobyov, V. Yarov-Yarovoy

This study uses Rosetta to model structural changes in hERG channels caused by mutations and drug interactions, revealing conformational shifts and binding mechanisms.

bioRxiv · Jul 8, 2021Biophysics

Sex-specific classification of drug-induced Torsade de Pointes susceptibility using cardiac simulations and machine learning

A. Fogli Iseppe, H. Ni, S. Zhu, X. Zhang, R. Coppini, P.-C. Yang, U. Srivatsa, C. E. Clancy, A. G. Edwards, S. Morotti, E. Grandi

This paper develops sex-specific TdP risk classifiers using cardiac simulations and machine learning, finding that male-based models underestimate female TdP risk.

Clinical Pharmacology & Therapeutics · Apr 19, 2021Peer-reviewedPharmacology & Toxicology

Atomistic modeling towards predictive cardiotoxicity

K. R. DeMarco, J. R. D. Dawson, P.-C. Yang, S. Bekker, V. A. Ngo, S. Y. Noskov, V. Yarov-Yarovoy, C. E. Clancy, I. Vorobyov

This paper develops a computational framework to distinguish safe and unsafe hERG blockers by modeling atomic interactions and simulating drug-channel dynamics.

bioRxiv · May 11, 2019 · PreprintBiophysics

Structural Basis for Antiarrhythmic Drug Interactions with the Human Cardiac Sodium Channel

P. T. Nguyen, K. R. DeMarco, I. Vorobyov, C. E. Clancy, V. Yarov-Yarovoy

This study investigates the molecular interactions of antiarrhythmic and local anesthetic drugs with hNav1.5 using structural modeling and simulations, revealing key binding sites and pathways.

bioRxiv · Sep 29, 2018Biophysics