Cell BiologybioRxivPreprint
Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope
M. Wallace, H. Zahr, S. Perati…·J. Lammerding
This study shows that LMNA mutations in iPSC-derived cardiomyocytes cause nuclear shape changes, reduced stiffness, and lamin mislocalization, linking nuclear abnormalities to LMNA-DCM pathogenesis.
DOI 10.1101/2021.10.30.466591