J. Lammerding

N-terminal tags impair the ability of Lamin A to provide structural support to the nucleus

This study shows that N-terminal tags on Lamin A affect its nuclear structural support functions but not all its roles in mammalian cells.

Microtubule forces drive nuclear damage in LMNA cardiomyopathy

This study shows that microtubule forces, not the LINC complex, drive nuclear damage in LMNA cardiomyopathy and that disrupting microtubules can rescue cardiac function.

Heterologous expression of Dictyostelium discoideum NE81 in mouse embryo fibroblasts reveals conserved mechanoprotective roles of lamins

This study expresses Dictyostelium lamin-like protein NE81 in mammalian cells to show conserved mechanoprotective roles of lamins in nuclear morphology and stability.

The Lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding

This study shows that the Lamin A/C Ig-fold undergoes cell density-dependent conformational changes that affect antibody binding, without altering protein levels or nuclear mechanics.

Rear cortex contraction aids in nuclear transit during confined migration by increasing pressure in the cell posterior

The paper identifies rear cortex contraction as a mechanism that increases intracellular pressure to facilitate nuclear transit during confined cell migration.

Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer

This study shows that low lamin A levels in breast cancer cells increase nuclear deformability and metastatic capacity, with lower lamin A levels linked to poorer disease-free survival in human tumors.

Eliminating elevated p53 signaling fails to rescue skeletal muscle defects or extend survival in Lamin A/C-deficient mice.

This study investigates whether reducing p53 activation can alleviate skeletal muscle defects in Lamin A/C-deficient mice, but finds no improvement in disease phenotype or survival.

PME-1 suppresses anoikis, and is associated with therapy relapse of PTEN-deficient prostate cancers

This study identifies PME-1 as a biomarker for aggressive PTEN-deficient prostate cancers by showing its role in suppressing anoikis.

ATM modulates nuclear mechanics by regulating lamin A levels

This study shows ATM regulates lamin A levels, affecting nuclear mechanics and cell migration.

Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response

This study shows that reducing Lamin-A/C levels enhances pro-inflammatory macrophage responses, and inhibiting its degradation or the IFN-β-STAT pathway can suppress inflammation.

Mucins form a nanoscale material barrier against immune cell attack

This study investigates how glycocalyx thickness, influenced by mucin properties, affects NK cell-mediated cytotoxicity and suggests strategies to enhance cancer immunotherapy.

Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope

This study shows that LMNA mutations in iPSC-derived cardiomyocytes cause nuclear shape changes, reduced stiffness, and lamin mislocalization, linking nuclear abnormalities to LMNA-DCM pathogenesis.

Confined migration induces heterochromatin formation and alters chromatin accessibility

The paper shows that confined cell migration induces heterochromatin formation and alters chromatin accessibility, which affects migration speed and cellular functions.

Nuclear deformation causes DNA damage by increasing replication stress

The paper shows that nuclear deformation during migration or compression causes DNA damage by increasing replication stress, primarily in S/G2 phase, independent of nuclear envelope rupture.

Lamin B2 follows lamin A/C- mediated nuclear mechanics and cancer cell invasion efficacy

The paper investigates the role of lamin B2 in nuclear mechanics and cancer cell invasion, finding that lamin B2 cooperates with lamin A/C to regulate nuclear deformability and migration efficacy.

Chemical-Genetic Interrogation of Nuclear Size Control Reveals Cancer-Specific Effects on Cell Migration and Invasion

The paper identifies compounds that reverse nuclear size changes in cancer cell lines and finds they inhibit cell migration and invasion.

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

This study shows that LMNA mutations cause nuclear envelope rupture and DNA damage in muscle cells, leading to disease through mechanical stress and DNA damage pathways.

High-throughput microfluidic micropipette aspiration device to probe time-scale dependent nuclear mechanics in intact cells

This paper introduces a microfluidic device for high-throughput measurement of time-dependent nuclear mechanics in cells, showing that lamin A/C loss increases nuclear deformability.