BiochemistrybioRxiv
Full Atomistic Model Of Prion Structure And Conversion
G. Spagnolli, M. Rigoli, S. Orioli…·J. R. Requena
The paper builds the first atomic-resolution model of mouse PrPSc using experimental data and computational methods, simulating the conversion of PrPC to PrPSc and providing a physically-coherent mechanism for prion propagation.