E. Biasini

A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

This paper identifies a small molecule inhibitor of UGGT, a key enzyme in ER glycoprotein folding, and demonstrates its inhibitory effects in vitro and in cell culture.

Structural Basis of Mutation-Dependent p53 Tetramerization Deficiency

This study investigates how mutations in p53's tetramerization domain affect its structure and function using simulations and yeast assays, showing destabilizing effects and altered transactivation.

Doxycycline inhibition of a pseudotyped virus transduction does not translate to inhibition of SARS-CoV-2 infectivity

This paper tests doxycycline's effect on SARS-CoV-2 infection using pseudovirus and clinical strains, finding it inhibits pseudovirus transduction but not actual SARS-CoV-2 entry and replication.

Solid state NMR reveals a parallel in register architecture for an infectious recombinant prion

The paper uses solid state NMR to analyze the structure of infectious recombinant prion, finding support for the parallel in register beta stack model over the 4-rung beta-solenoid model.

All-Atom Simulation of the HET-s Prion Replication

This study uses all-atom simulations to investigate HET-s prion replication, finding similarities in templating mechanisms between fungal and mammalian prions.

Structural features of an infectious recombinant PrPSc prion using solid state NMR

This study uses solid-state NMR to analyze the structure of a recombinant PrPSc prion and validates a proposed atomistic model of its beta-solenoid structure.

PHARMACOLOGICAL PROTEIN INACTIVATION BY TARGETING FOLDING INTERMEDIATES

The paper discovers non-native metastable states in protein folding pathways and develops a novel drug discovery approach, PPI-FIT, to target these intermediates to lower protein expression.

Full Atomistic Model Of Prion Structure And Conversion

The paper builds the first atomic-resolution model of mouse PrPSc using experimental data and computational methods, simulating the conversion of PrPC to PrPSc and providing a physically-coherent mechanism for prion propagation.