Author

P. Faccioli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Approach:deep learning· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:fungi (other)· 1

Frequent Co-Authors

G. Spagnolli· 4 shared A. Boldrini· 3 shared E. Biasini· 3 shared J. R. Requena· 3 shared L. Terruzzi· 3 shared M. Rigoli· 2 shared S. Orioli· 2 shared A. Astolfi· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersBiophysics

G. Spagnolli

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Author profile →

4 papers

Recent·Most cited

Long range allostery mediates the regulation of plasminogen activator inhibitor 1 by vitronectin

K. Kihn, E. Marchiori, G. Spagnolli, A. Boldrini, L. Terruzzi, D. A. Lawrence, A. Gershenson, P. Faccioli, P. L. Wintrode

This study uses simulations to show vitronectin regulates PAI-1 latency transition by reducing RCL and gate mobility through long-range allostery, revealing a cryptic drug binding site.

bioRxiv · Jul 19, 2022 · PreprintBiophysics

All-Atom Simulation of the HET-s Prion Replication

L. Terruzzi, G. Spagnolli, A. Boldrini, J. R. Requena, E. Biasini, p. faccioli

This study uses all-atom simulations to investigate HET-s prion replication, finding similarities in templating mechanisms between fungal and mammalian prions.

PLOS Computational Biology · Sep 18, 2020Peer-reviewedBiophysics

PHARMACOLOGICAL PROTEIN INACTIVATION BY TARGETING FOLDING INTERMEDIATES

G. Spagnolli, T. Massignan, A. Astolfi, S. Biggi, P. Brunelli, M. Libergoli, A. Ianeselli, S. Orioli, A. Boldrini, L. Terruzzi, G. Maietta, M. Rigoli, N. Lopez Lorenzo, L. C. Fernandez, L. Tosatto, , E. Biasini

The paper discovers non-native metastable states in protein folding pathways and develops a novel drug discovery approach, PPI-FIT, to target these intermediates to lower protein expression.

bioRxiv · Mar 31, 2020 · PreprintBiochemistry

Full Atomistic Model Of Prion Structure And Conversion

G. Spagnolli, M. Rigoli, S. Orioli, A. M. Sevillano, P. Faccioli, H. Wille, E. Biasini, J. R. Requena

The paper builds the first atomic-resolution model of mouse PrPSc using experimental data and computational methods, simulating the conversion of PrPC to PrPSc and providing a physically-coherent mechanism for prion propagation.

bioRxiv · Dec 22, 2018Biochemistry