The replication stress response suppresses mutation rates in mismatch repair deficient budding yeast and human cancers
A. M. Shrikhande, S. G. Soerensen, J. Offman, B. Domanska, J. S. Pedersen, E. R. Hoffmann
The paper shows mutation rates in MMR-deficient cells are genetically regulated, with some gene deletions increasing and others decreasing MSI rates across species.
bioRxiv · Apr 28, 2022 · PreprintCancer Biology