J. S. Pedersen

Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations

This study shows that fecal microbial load, not disease, is the main driver of gut microbiome changes and identifies it as a major confounder in microbiome studies.

Error-corrected deep targeted sequencing of circulating cell-free DNA from colorectal cancer patients for sensitive detection of circulating tumor DNA

UMIseq detects circulating tumor DNA in colorectal cancer patients with high sensitivity and specificity, even at low allele frequencies.

A targetable N-terminal motif orchestrates α-synuclein oligomer to fibril conversion

This study identifies an N-terminal motif in α-synuclein oligomers that drives fibril conversion and shows how a mutation disrupts this process, offering a new therapeutic target.

Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

This study presents the crystal structure of Toxoplasma gondii GAC and proposes a multi-conformational model for its assembly in the glideosome.

The replication stress response suppresses mutation rates in mismatch repair deficient budding yeast and human cancers

The paper shows mutation rates in MMR-deficient cells are genetically regulated, with some gene deletions increasing and others decreasing MSI rates across species.

Human myelin proteolipid protein structure and lipid bilayer stacking

This study determines the structure of human myelin proteolipid protein (PLP) and its isoform DM20, revealing their dimeric conformation and role in membrane stacking and organization.

Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin-antitoxin system

The paper investigates the structural basis of kinase inhibition in the E. coli HipBST toxin-antitoxin system, showing how HipS inhibits HipT through active site insertion and how phosphorylation affects complex flexibility.

Sequence dependencies and mutation rates of localized mutational processes in cancer

The paper analyzes mutation rates of 11-mer sequence contexts across cancer genomes to identify localized mutational processes and their sequence preferences.

Structural insights on the substrate-binding proteins of the Mycobacterium tuberculosis mammalian-cell-entry (Mce) 1 and 4 complexes

This study reports the structural properties of Mce substrate-binding proteins from Mycobacterium tuberculosis, revealing a novel heterohexameric arrangement and domain-specific interactions.

Isolation and complete genome sequencing of Pectobacterium phage Jarilo, representing a novel genus of bacteriophages within the subfamily Autographivirinae

The paper isolates and characterizes Pectobacterium phage Jarilo, a novel bacteriophage in the Autographivirinae subfamily with a 40557 bp genome and 50 ORFs.

NOD1 mediates non-canonical inflammasome processing of interleukin-18 in epithelial cells to Helicobacter pylori infection.

This study identifies NOD1 as a key regulator of IL-18 processing in epithelial cells during Helicobacter pylori infection, independent of canonical inflammasome proteins.

Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival

The paper identifies non-coding mutations associated with cancer by analyzing conservation, mutational patterns, and correlations with gene expression and survival across multiple cancer types.