Author

E. R. Hoffmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

A. B. Abildgaard· 1 shared A. M. Shrikhande· 1 shared A. Shrikhande· 1 shared A. Stein· 1 shared A.-M. Gerdes· 1 shared B. Domanska· 1 shared C. Ishioka· 1 shared E. Papaleo· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. B. Abildgaard

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Author profile →

2 papers

Recent·Most cited

The replication stress response suppresses mutation rates in mismatch repair deficient budding yeast and human cancers

A. M. Shrikhande, S. G. Soerensen, J. Offman, B. Domanska, J. S. Pedersen, E. R. Hoffmann

The paper shows mutation rates in MMR-deficient cells are genetically regulated, with some gene deletions increasing and others decreasing MSI rates across species.

bioRxiv · Apr 28, 2022 · PreprintCancer Biology

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

A. B. Abildgaard, A. Stein, S. V. Nielsen, K. Schultz-Knudsen, E. Papaleo, A. Shrikhande, E. R. Hoffmann, I. Bernstein, A.-M. Gerdes, M. Takahashi, C. Ishioka, K. Lindorff-Larsen, R. Hartmann-Petersen

The paper identifies structural destabilization and degradation of MLH1 variants in Lynch syndrome, linking reduced cellular levels to loss-of-function and suggesting stability predictions for diagnostic use.

bioRxiv · Oct 13, 2019Biochemistry