Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30
Y. Liu, R. McIntyre, G. Janssens, E. Williams, J. Lan, H. van Veen, N. van der Wel, W. B. Mair, R. Aebersold, A. MacInnes, R. Houtkooper
This study shows that inhibiting both mitochondrial translation and dynamics in C. elegans synergistically extends lifespan through HLH-30-dependent lysosome biogenesis and autophagy.
bioRxiv · Dec 10, 2019Cell Biology