R. Houtkooper

Human inborn errors of long-chain fatty acid oxidation show impaired inflammatory responses to TLR4-ligand LPS

This study shows that mutations in ETFDH and ACADVL, which are involved in long-chain fatty acid oxidation, impair inflammatory responses to LPS by reducing TLR4 expression and cytokine production.

Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction and leads to increased glucose uptake in tafazzin-deficient cells

This study identifies the upregulation of the AMPK-FOXO1-PDK4 pathway as the mechanism causing reduced PDH activity and increased glucose uptake in tafazzin-deficient cells.

Treatment with a selective histone deacetylase (HDAC) 1 and 2 inhibitor in aged mice rejuvenates multiple organ systems

This paper identifies a selective HDAC1/2 inhibitor, Cmpd60, that rejuvenates multiple organ systems in aged mice through transcriptional effects mimicking genetic longevity interventions.

Human ovarian ageing is characterized by oxidative damage and mitochondrial dysfunction

This study identifies oxidative damage and mitochondrial dysfunction in human oocytes during ovarian ageing using immunofluorescence, metabolomics, and lipidomics.

Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30

This study shows that inhibiting both mitochondrial translation and dynamics in C. elegans synergistically extends lifespan through HLH-30-dependent lysosome biogenesis and autophagy.

Identification of key pathways and metabolic fingerprints of longevity in C. elegans

This study identifies shared metabolic pathways and signatures of longevity in C. elegans by integrating transcriptomics and metabolomics data from IIS and CR models.