A. Marciniak-Czochra

This study identifies SFRP1 as a therapeutic target for glioblastoma by revealing its role in reprogramming tumor methylomes and improving survival in mouse models.

This study investigates genotype-phenotype relationships in Down Syndrome ALL, showing that genetic and phenotypic heterogeneity influences treatment response and relapse through clonal competition.

This study develops a computational algorithm to reconstruct clonal hierarchies from bulk sequencing data of acute myeloid leukemia samples, showing that few hierarchies fit the data, suggesting bulk data can inform clonal evolution.

This study uses mathematical modeling to show that cytokine-independent leukemic cell proliferation is linked to poor patient outcomes in AML.