A. Goncalves

Type 1 immunity enables neonatal thymic ILC1 production

The paper shows type 1 immunity drives thymic production and peripheral migration of ILC1s in neonates.

The unique Legionella longbeachae capsule favors intracellular replication and immune evasion

This study identifies a unique capsule in Legionella longbeachae that enhances intracellular replication and immune evasion, distinguishing it from other Legionella species.

Regenerative cell turnover coupled to a tumor-hostile niche protects naked mole-rats from cancer

This study identifies a tumor-suppressive strategy in naked mole-rats that couples regenerative cell turnover with a tumor-hostile stromal niche to prevent cancer.

Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression

This study identifies SFRP1 as a therapeutic target for glioblastoma by revealing its role in reprogramming tumor methylomes and improving survival in mouse models.

Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs

The paper identifies antioxidant-capacity biomarkers (ACBs) that predict susceptibility to ROS-inducing drugs in lung cancer cells, showing that low ACB expression correlates with nitric oxide levels, not ROS levels.

Phase separation-based visualization of protein-protein interactions and kinase activities in plants

The paper introduces a phase separation-based method to visualize protein-protein interactions and kinase activities in plants using the SYMPL vector set.

Spatial proteogenomics reveals distinct and evolutionarily-conserved hepatic macrophage niches

This study creates a spatial proteogenomic atlas of the liver across species, identifying conserved macrophage niches and their regulatory mechanisms.

Carbohydrate binding domains facilitate efficient oligosaccharides synthesis by enhancing mutant catalytic domain transglycosylation activity

This study shows carbohydrate-binding domains enhance catalytic activity in chimeric CAZymes for efficient oligosaccharide synthesis.

Conjunctival microbiome-host responses are associated with impaired epithelial cell health in both early and late stages of trachoma

This study links changes in the conjunctival microbiome and host immune responses to impaired epithelial cell health in trachoma, with distinct patterns in active trachoma and scarring trachoma.

The CARD-CC/Bcl10/paracaspase signaling complex is functionally conserved since the last common ancestor of planulozoa.

This study identifies the ancient conservation of the CARD-CC/Bcl10/paracaspase signaling complex across planulozoa, including invertebrates and vertebrates.