Linking T cell receptor sequence to transcriptional profiles with clonotype neighbor graph analysis (CoNGA)
S. Schattgen, K. Guion, J. C. Crawford, A. Souquette, A. Martinez Barrio, M. J. T. Stubbington, P. G. Thomas, P. Bradley
The paper introduces CoNGA, a graph-theoretic method to analyze relationships between TCR sequences and gene expression in T cells, revealing known and novel associations across human and mouse datasets.
bioRxiv · Jun 4, 2020Immunology