Author

J. C. Crawford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Organism:human· 7 Approach:experimental assay· 6 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3

Frequent Co-Authors

P. G. Thomas· 5 shared A. Souquette· 3 shared S. Schattgen· 3 shared S. Schultz-Cherry· 3 shared A. Ellebedy· 2 shared A. Haile· 2 shared A. J. Schmitz· 2 shared J. S. Turner· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersImmunology

P. G. Thomas

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Spatiotemporal development of the human T follicular helper cell response to Influenza vaccination

S. Schattgen, J. S. Turner, M. A. Ghonim, J. C. Crawford, A. J. Schmitz, H. Kim, J. Q. Zhou, W. Awad, W. Kim, K. M. McIntire, A. Haile, M. K. Klebert, T. Suessen, W. D. Middleton, S. A. Teefey, , P. Thomas

This study tracks the spatiotemporal dynamics of human T follicular helper (TFH) cells after influenza vaccination, showing clonal expansion, phenotypic changes, and lineage-specific responses over two years.

bioRxiv · Aug 29, 2023 · PreprintImmunology

The beta 6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection

M. Smith, V. A. Meliopoulos, S. Tan, T. Bub, P. H. Brigleb, B. Sharp, J. C. Crawford, M. S. Prater, S. M. Pruett-Miller, S. Schultz-Cherry

This study shows that beta 6 integrin suppresses TLR7-mediated epithelial immunity during influenza A virus infection by promoting autophagy and altering TLR7 trafficking.

bioRxiv · Aug 28, 2023 · PreprintImmunology

Establishing thresholds for cytokine storm and defining their relationship to disease severity in respiratory viral infections

A. Souquette, J. C. Crawford, J. Wolf, A. Blair, M. Agrawal, L. Boywid, K. McNair, N. D. Hysmith, C. Hundman, A. Bahadoran, S. R. Arnold, SJTRC Study Team, H. Smallwood, A. Green, P. G. Thomas

This study identifies cytokine thresholds and their relationship to disease severity in respiratory viral infections, showing that hypercytokinemia is not strongly linked to severity and that certain cytokines may predict long COVID risk.

bioRxiv · Jul 6, 2023 · PreprintImmunology

Astrovirus replication is dependent on induction of double membrane vesicles through a PI3K-dependent, LC3-independent pathway

T. Bub, V. Hargest, S. Tan, M. Smith, A. Vazquez-Pagan, T. Flerlage, P. H. Brigleb, V. A. Meliopoulos, B. D. Lindenbach, V. Cortez, J. C. Crawford, S. Schultz-Cherry

This study shows astrovirus replication depends on PI3K-dependent, LC3-independent DMV formation, suggesting PI3K as a therapeutic target for viral infections.

bioRxiv · Apr 11, 2023 · PreprintMicrobiology

Latent human herpesvirus 6 is reactivated in chimeric antigen receptor T cells

C. A. Lareau, Y. Yin, K. Maurer, K. D. Sandor, G. Yagnik, J. Pena, J. C. Crawford, A. M. Spanjaart, J. C. Gutierrez, N. J. Haradvala, T. Abay, R. R. Stickels, J. M. Verboon, V. Liu, J. Southard, , A. T. Satpathy

The paper identifies HHV-6 reactivation in CAR T cells using single-cell sequencing and links it to clinical neurotoxicity observed in patients.

bioRxiv · Aug 12, 2022 · PreprintImmunology

SARS-CoV-2 mRNA vaccination elicits robust and persistent T follicular helper cell response in humans

P. A. Mudd, A. A. Minervina, M. V. Pogorelyy, J. S. Turner, W. Kim, E. Kalaidina, J. Petersen, A. J. Schmitz, T. Lei, A. Haile, A. M. Kirk, R. C. Mettelman, J. C. Crawford, T. H. O. Nguyen, L. C. Rowntree, , A. Ellebedy

This study shows that SARS-CoV-2 mRNA vaccination leads to strong and long-lasting T follicular helper cell responses in humans.

bioRxiv · Sep 8, 2021Immunology

Neuroblastoma formation requires unconventional CD4 T cells and myeloid amino acid metabolism

L.-A. Van de Velde, E. K. Allen, J. C. Crawford, T. L. Wilson, C. S. Guy, M. Russier, L. Zeitler, A. Bahrami, D. Finkelstein, S. Pelletier, S. Schultz-Cherry, P. G. Thomas, P. J. Murray

This study identifies unconventional CD4 T cells and myeloid amino acid metabolism as critical for neuroblastoma formation using a mouse model and spatial transcriptomics.

bioRxiv · Feb 8, 2021Cancer Biology

TCR meta-clonotypes for biomarker discovery with tcrdist3: identification of public, HLA-restricted SARS-CoV-2 associated TCR features

K. Mayer-Blackwell, S. Schattgen, L. Cohen-Lavi, J. C. Crawford, A. Souquette, J. A. Gaevert, T. Hertz, P. G. Thomas, P. Bradley, A. Fiore-Gartland

The paper introduces meta-clonotypes for TCR analysis, identifies HLA-restricted SARS-CoV-2 TCR features, and develops tcrdist3 for repertoire analysis.

bioRxiv · Dec 24, 2020Immunology

Linking T cell receptor sequence to transcriptional profiles with clonotype neighbor graph analysis (CoNGA)

S. Schattgen, K. Guion, J. C. Crawford, A. Souquette, A. Martinez Barrio, M. J. T. Stubbington, P. G. Thomas, P. Bradley

The paper introduces CoNGA, a graph-theoretic method to analyze relationships between TCR sequences and gene expression in T cells, revealing known and novel associations across human and mouse datasets.

bioRxiv · Jun 4, 2020Immunology