Author

A. Souquette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7

Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:cell type annotation· 4 Research Focus:gene regulatory network inference· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

P. G. Thomas· 6 shared J. C. Crawford· 3 shared A. Balmaseda· 2 shared A. Gordon· 2 shared A. Green· 2 shared B. Ogunjimi· 2 shared E. K. Allen· 2 shared G. Elias· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersImmunology

P. G. Thomas

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Author profile →

7 papers

Recent·Most cited

Utility of nasal swabs for assessing mucosal immune responses towards SARS-CoV-2

E. K. Roubidoux, P. H. Brigleb, K. Vegesana, A. Souquette, K. Whitt, P. Freiden, St. Jude Investigative Team, A. Green, P. G. Thomas, M. A. McGargill, J. Wolf, S. Schultz-Cherry

This study shows nasal swabs can assess mucosal immune responses to SARS-CoV-2, revealing distinct cytokine and antibody profiles compared to systemic responses.

bioRxiv · Jul 12, 2023Immunology

Establishing thresholds for cytokine storm and defining their relationship to disease severity in respiratory viral infections

A. Souquette, J. C. Crawford, J. Wolf, A. Blair, M. Agrawal, L. Boywid, K. McNair, N. D. Hysmith, C. Hundman, A. Bahadoran, S. R. Arnold, SJTRC Study Team, H. Smallwood, A. Green, P. G. Thomas

This study identifies cytokine thresholds and their relationship to disease severity in respiratory viral infections, showing that hypercytokinemia is not strongly linked to severity and that certain cytokines may predict long COVID risk.

bioRxiv · Jul 6, 2023 · PreprintImmunology

Integrated Drivers of Basal and Acute Immunity in Diverse Human Populations

A. Souquette, E. K. Allen, C. M. Oshansky, L. Tang, S.-s. Wong, T. Jeevan, L. Shi, S. Pounds, G. Elias, G. Kuan, A. Balmaseda, R. Zapata, K. Shaw-Saliba, P. Van Damme, V. Van Tendeloo, , P. G. Thomas

The paper examines factors influencing immunity across diverse populations, finding ancestry and age significantly affect immune responses and disease severity.

bioRxiv · Mar 25, 2023Immunology

Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

M. L. Russell, A. Souquette, D. M. Levine, E. K. Allen, G. Kuan, N. Simon, A. Balmaseda, A. Gordon, P. Thomas, F. A. Matsen, P. G. Bradley

The paper infers genetic loci influencing V(D)J recombination probabilities by combining TCR repertoires and genome-wide genotypes from a human cohort.

bioRxiv · Sep 17, 2021Immunology

TCR meta-clonotypes for biomarker discovery with tcrdist3: identification of public, HLA-restricted SARS-CoV-2 associated TCR features

K. Mayer-Blackwell, S. Schattgen, L. Cohen-Lavi, J. C. Crawford, A. Souquette, J. A. Gaevert, T. Hertz, P. G. Thomas, P. Bradley, A. Fiore-Gartland

The paper introduces meta-clonotypes for TCR analysis, identifies HLA-restricted SARS-CoV-2 TCR features, and develops tcrdist3 for repertoire analysis.

bioRxiv · Dec 24, 2020Immunology

Preexisting memory CD4 T cells in nÏave individuals confer robust immunity upon hepatitis B vaccination

G. Elias, P. Meysman, E. Bartholomeus, N. De Neuter, N. Keersmaekers, A. Suls, H. Jansens, A. Souquette, H. De Reu, E. Smits, E. Lion, P. G. Thomas, G. Mortier, P. Van Damme, P. Beutels, , B. Ogunjimi

The paper shows preexisting memory CD4 T cells in unvaccinated individuals correlate with stronger hepatitis B vaccine responses and predicts immune outcomes using TCR sequencing and machine learning.

bioRxiv · Aug 22, 2020Immunology

Linking T cell receptor sequence to transcriptional profiles with clonotype neighbor graph analysis (CoNGA)

S. Schattgen, K. Guion, J. C. Crawford, A. Souquette, A. Martinez Barrio, M. J. T. Stubbington, P. G. Thomas, P. Bradley

The paper introduces CoNGA, a graph-theoretic method to analyze relationships between TCR sequences and gene expression in T cells, revealing known and novel associations across human and mouse datasets.

bioRxiv · Jun 4, 2020Immunology