Non-canonical glutamate-cysteine ligase activity protects against ferroptosis
Y. P. Kang, A. Mockabee-Macias, C. Jiang, I. S. Harris, G. M. DeNicola
This study identifies a non-canonical role of glutamate-cysteine ligase in preventing glutamate accumulation and ferroptosis under cystine starvation.
bioRxiv · May 29, 2020Cancer Biology