Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
V. Rawat, P. DeLear, P. Prashanth, M. E. Ozgurses, A. Tebeje, P. A. Burns, K. O. Conger, C. Solis, Y. Hasnain, A. Novikova, J. E. Endress, P. Gonzalez-Sanchez, W. Dong, G. Stephanopoulos, G. M. DeNicola, , J. L. Coloff
The paper screens drugs in human physiologic medium and identifies uric acid as an inhibitor of rigosertib's efficacy.
bioRxiv · Jul 26, 2023Cancer Biology
L. Bonetti, V. Horkova, J. Longworth, L. Guerra, H. Kurniawan, D. G. Franchina, L. Soriano-Baguet, M. Grusdat, S. Spath, E. Koncina, A. Ewen, C. Binsfeld, C. Verscheuren, J.-J. Gerardy, T. Kobayashi, , D. Brenner
This study identifies a Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis that protects against intestinal inflammation by maintaining barrier integrity and preventing mortality from C. rodentium infection.
bioRxiv · Jul 6, 2023Immunology
M. H. Raymonda, I. Rodriguez-Sanchez, X. Schafer, L. Smorodintsev-Schiller, I. S. Harris, J. Munger
This paper shows that HCMV's UL38 protein inactivates TSC2, disrupting glucose-fatty acid biosynthesis coupling and making cells vulnerable to glucose limitation.
bioRxiv · May 17, 2023 · PreprintMicrobiology
G. Asantewaa, E. T. Tuttle, N. P. Ward, Y. P. Kang, Y. Kim, M. E. Kavanagh, N. Girnius, Y. Chen, R. Duncan, K. Rodriguez, F. Hecht, M. Zocchi, L. Smorodintsev-Schiller, T. Q. Scales, K. Taylor, , I. S. Harris
This study shows that glutathione (GSH) is essential for lipid abundance in adult tissues, particularly in the liver, by repressing NRF2.
bioRxiv · Feb 10, 2023 · PreprintBiochemistry
B. T. Do, P. P. Hsu, S. Y. Vermeulen, Z. Wang, T. Hirz, K. L. Abbott, N. Aziz, J. M. Replogle, S. Bjelosevic, J. Paolino, S. Nelson, S. Block, A. M. Darnell, R. Ferreira, H. Zhang, , M. G. Vander Heiden
The paper shows that nucleotide depletion and DNA replication stress drive cell fate transitions in hematopoietic systems by activating lineage-specific maturation genes.
bioRxiv · Aug 16, 2022Cancer Biology
D. D. Shi, M. R. Savani, M. M. Levitt, A. C. Wang, J. E. Endress, C. E. Bird, J. Buehler, S. A. Stopka, M. S. Regan, Y.-F. Lin, W. Gao, J. Khanal, M. Xu, B. Huang, R. B. Jennings, , McBray
This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.
bioRxiv · Nov 30, 2021Cancer Biology
M. H. Raymonda, J. H. Ciesla, M. Monaghan, J. Leach, G. Asantewaa, L. A. Smorodintsev-Schiller, M. M. Lutz, X. L. Schafer, T. Takimoto, S. Dewhurst, J. Munger, I. S. Harris
This study identifies lapatinib as a potent antiviral against SARS-CoV-2 in vitro, showing over 50,000-fold inhibition without toxicity.
bioRxiv · Nov 25, 2020Microbiology
Y. P. Kang, A. Mockabee-Macias, C. Jiang, I. S. Harris, G. M. DeNicola
This study identifies a non-canonical role of glutamate-cysteine ligase in preventing glutamate accumulation and ferroptosis under cystine starvation.
bioRxiv · May 29, 2020Cancer Biology