The apparent requirement for protein synthesis during G2 phase is due to checkpoint activation
S. Lockhead, A. Moskaleva, J. Kamenz, Y. Chen, M. Kang, A. R. K. Reddy, S. Santos, J. E. Ferrell
The study shows cycloheximide arrests cells in G2 phase due to p38 MAPK activation, not protein synthesis inhibition, indicating G2 protein synthesis is not required for mitotic entry.
bioRxiv · Dec 3, 2019Cell Biology