M. Kang

TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway

This study shows that TOMM40 regulates lipid metabolism in hepatocytes through an LXR-dependent pathway, affecting plasma lipid levels and hepatic lipid droplet accumulation.

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly

This study identifies CLCC1 as a regulator of hepatic neutral lipid flux and nuclear pore complex assembly through CRISPR screens and functional analyses.

Loss of p21-activated kinase 4 (PAK4) suppresses pancreatic tumor progression and metastasis through regulating E-cadherin

This study shows that PAK4 promotes pancreatic cancer metastasis by reducing E-cadherin, and its loss inhibits tumor progression and metastasis.

Quantitative single cell mass spectrometry reveals the dynamics of plant natural product biosynthesis

The paper develops a method for single cell mass spectrometry to quantify natural products in plant cells, revealing biosynthetic dynamics not captured by scRNA-seq.

Cardiaca adipokinetic hormone and hedgehog signaling combine to generate intracellular waves of Ca++ in starved Drosophila melanogaster fat body

This study shows that AKH and Hedgehog signaling in Drosophila fat body generate intracellular Ca++ waves during fasting, integrating signals from the brain and midgut.

The focal adhesion protein talin is a mechanically-gated A-kinase anchoring protein (AKAP)

This study identifies talin1 as a mechanically-gated AKAP that binds PKA through a force-dependent interaction in focal adhesions.

AI-driven Classification of Cancer-Associated Fibroblasts Using Morphodynamic and Motile Features

This paper introduces an AI framework to classify cancer-associated fibroblasts using morphodynamic and motile features from live-cell imaging, complementing biomolecular approaches.

An RXLR effector targets ER-Golgi interface to induce ER stress and necrotic cell death

This study identifies Pc12, an RXLR effector from P. capsici, which induces necrotic cell death by disrupting ER-Golgi trafficking through interaction with Rab13-2.

RAG-17: A Novel siRNA Conjugate Demonstrating Efficacy in Late-Stage Treatment of SOD1G93A ALS mice

This study introduces RD-12500, an siRNA conjugate that effectively reduces SOD1 levels and delays disease progression in late-stage SOD1G93A ALS mice.

Protein Kinase A is Functional Component of Focal Adhesions

This study identifies PKA as a functional component of focal adhesions and identifies Tns3 as a novel PKA substrate, revealing a new pathway for phospho-regulation in FA dynamics.

Differential expression of tension-sensitive HOX genes in fibroblasts is associated with different scar types

The paper identifies differential expression of tension-sensitive HOX genes in fibroblasts across scar types and links it to tensional homeostasis in wound healing.

Local administration of a novel siRNA modality into the CNS extends survival and improves motor function in the SOD1G93A mouse model for ALS

This study demonstrates that a novel siRNA modality, conjugated with an accessory oligonucleotide, improves survival and motor function in a mouse model of ALS when delivered locally to the CNS.

Protein Kinase A Activity In The Leading Edge Of Migrating Cells Is Dependent On The Activity Of Focal Adhesion Kinase

This study shows that FAK activity is required for localized PKA regulation in migrating cells, establishing a novel connection between adhesion signaling and PKA activity.

Existence of blood circulating immune-cell clusters (CICs) comprising antigen-presenting cells and B cells

The paper identifies circulating immune-cell clusters (CICs) composed of antigen-presenting cells and B cells in blood, showing increased frequency in COVID-19 patients.

Ultramicrobacteria in various fermented cabbages

This study identifies ultramicrobacteria in fermented cabbages using advanced sequencing and microscopy, revealing their diversity and potential ecological significance.

Label-free adaptive optics single-molecule localization microscopy for whole animals

This paper develops a label-free adaptive optics method for SMLM, enabling deep-tissue super-resolution imaging in whole animals by correcting tissue aberrations.

Single-cell RNA-sequencing of Nicotiana attenuata petal cells reveals the entire biosynthetic pathway of a floral scent

The paper uses scRNA-seq to identify cell populations in Nicotiana attenuata petals and uncover the biosynthetic pathway of benzylacetone.

Rapid label-free identification of pathogenic bacteria species from a minute quantity 1 exploiting three-dimensional quantitative phase imaging and artificial neural network

This paper develops a framework for rapid bacterial species identification using 3D quantitative phase imaging and artificial neural networks, achieving 99.9% accuracy with single colony-forming units.

Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation

This study identifies drug-induced secretome fucosylation as a mechanism of resistance to targeted therapies across multiple cancers.

Agency rescues competition for credit assignment among predictive cues from adverse learning conditions

The paper shows that agency over learning can restore cue competition in adverse conditions, improving credit assignment accuracy.

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.

Human spinal cord organoids exhibiting neural tube morphogenesis for a quantifiable drug screening system of neural tube defects

This study develops human spinal cord-like organoids (hSCOs) to enable quantitative drug screening for neural tube defects.

Rapid tolerance to morphine in the myenteric neurons of the small intestine is independent of β-arrestin-2 and mediated by PKC

This study shows that morphine tolerance in the small intestine develops rapidly and is independent of β-arrestin-2 but mediated by PKC, unlike peripheral antinociceptive tolerance.

Differential TM4SF5-mediated SIRT1 modulation and signaling for chronic liver disease

This study identifies TM4SF5's role in modulating SIRT1 and STAT3 signaling during NAFL to NASH progression, showing age-dependent effects and potential therapeutic targets.

Fitness Functions Determine Optimal Parental Allocation: Redefining Trivers Willard Theory

The paper mathematically shows that reversed Trivers-Willard theory can result from parental fitness optimization, depending on the fitness functions used.

The apparent requirement for protein synthesis during G2 phase is due to checkpoint activation

The study shows cycloheximide arrests cells in G2 phase due to p38 MAPK activation, not protein synthesis inhibition, indicating G2 protein synthesis is not required for mitotic entry.

Structural and molecular insight into the pH-induced low-permeability of the voltage-gated potassium channel Kv1.2 through dewetting of the water cavity

This study identifies two residues in Kv1.2 that act as a pH switch, showing how protonation disrupts electrostatic balance and causes channel closure through dewetting of the water cavity.

IL-1RA controls the development of esophageal cancer by inhibition of VEGF via PI3K/NF-κB signaling pathway

This study shows IL-1RA inhibits esophageal cancer progression by suppressing VEGF through the PI3K/NF-κB pathway, suggesting it as a potential therapeutic target.

Molecular evolution, diversity and adaptation of H7N9 influenza A viruses in China

The paper analyzes the evolution and adaptation of H7N9 influenza viruses in China, identifying lineage-specific mutations and high-pathogenicity strains.