Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade
H.-W. Tseng, A. Mota-Sydor, R. Leventis, I. Topisirovic, T. Duchaine
The paper identifies CFIm59 and CFIm68 as regulators of Pten APA, showing their opposing roles in PTEN dosage and PI3K/Akt signaling in cancer.
bioRxiv · Sep 9, 2021Biochemistry