I. Topisirovic

Epigenetic coordination of transcriptional and translational programs in hypoxia

The paper shows hypoxia induces TSS switching via H3K4me3 changes, altering translation of key metabolic genes like PDK1.

Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.

The paper investigates the effects of LONP2 depletion on peroxisomal function and cholesterol metabolism, revealing cell-type-specific responses and implications for peroxisomal disorders.

Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade

The paper identifies CFIm59 and CFIm68 as regulators of Pten APA, showing their opposing roles in PTEN dosage and PI3K/Akt signaling in cancer.

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation

This study identifies mTORC1-dependent translation as a mechanism for endo-lysosome expansion and antigen presentation during phagocyte activation.

Translational control of breast cancer plasticity

The paper identifies hypoxia and drug-induced translational activation of NANOG, SNAIL, and NODAL isoforms that drive breast cancer plasticity and stem-cell-like phenotypes, with potential therapeutic implications.

Translational and HIF1α-dependent metabolic reprograming underpin oncometabolomeplasticity and synergy between oncogenic kinase inhibitors and biguanides.

This study identifies translational reprogramming of non-essential amino acid synthesis and HIF1-dependent reductive glutamine metabolism as key factors enabling synergy between kinase inhibitors and biguanides in cancer cells.