The palmitoyl acyltransferase DHHC5 mediates beta-adrenergic signaling in the heart by targeting Gα proteins and G protein-coupled receptor kinase 2
J. J. Chen, A. N. Marsden, A. M. Akimzhanov, D. Boehning
This study shows that DHHC5 mediates beta-adrenergic signaling in the heart by palmitoylating Gα proteins and GRK2, essential for downstream functional responses.
bioRxiv · Jul 17, 2018Cell Biology