Stable transplantation of human mitochondrial DNA by high-throughput, pressurized mitochondrial delivery
A. J. Sercel, A. N. Patananan, T. Man, T.-H. Wu, A. K. Yu, G. W. Guyot, S. Rabizadeh, K. R. Niazi, P.-Y. Chiou, M. A. Teitell
This paper develops MitoPunch, a device for delivering mitochondria to cells, enabling stable retention of exogenous mtDNA and creating SIMR cells with specific mtDNA-nDNA combinations.
bioRxiv · Sep 15, 2020Cell Biology