ShcA promotes chondrocyte hypertrophic commitment and osteoarthritis in mice through RunX2 nuclear translocation and YAP1 inactivation
A. Abou-Jaoude, M. Courtes, L. Badique, D. Elhaj Mahmoud, C. Abboud, M. Mlih, H. Justiniano, A. Lemle, S. Awan, J. Terrand, A. Niemeier, A. Barbero, X. Houard, P. Boucher, R. L. Matz
This study shows that ShcA promotes chondrocyte hypertrophy and osteoarthritis in mice by facilitating RunX2 nuclear translocation and inhibiting YAP1.
bioRxiv · Jul 16, 2020Physiology