Author

A. O. Kwok

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

B. Norton-Baker· 1 shared D. von Stetten· 1 shared K. W. Roskamp· 1 shared M. A. Spague-Piercy· 1 shared P. Mehrabi· 1 shared R. J. D. Miller· 1 shared R. W. Martin· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

B. Norton-Baker

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1 paper

Recent·Most cited

Deamidation of the human eye lens protein γS-crystallin accelerates oxidative aging

B. Norton-Baker, P. Mehrabi, A. O. Kwok, K. W. Roskamp, M. A. Spague-Piercy, D. von Stetten, R. J. D. Miller, R. W. Martin

This study reports six crystal structures of deamidated γS-crystallin variants, showing increased instability, aggregation, and disulfide bond formation, suggesting deamidation accelerates oxidative aging in the human lens.

Structure · May 1, 2022Peer-reviewedBiochemistry