B. Norton-Baker

Integration of pH control into Chi.Bio reactors and demonstration with small-scale enzymatic poly(ethylene terephthalate) hydrolysis

The paper enhances the Chi.Bio bioreactor with pH control, demonstrating its effectiveness in PET hydrolysis with reduced enzyme requirements.

Deamidation of the human eye lens protein γS-crystallin accelerates oxidative aging

This study reports six crystal structures of deamidated γS-crystallin variants, showing increased instability, aggregation, and disulfide bond formation, suggesting deamidation accelerates oxidative aging in the human lens.

Course-based Undergraduate Research Module for Enzyme Discovery Using Protein Structure Prediction

This paper describes a course module that teaches protein structure fundamentals through enzyme discovery research, using comparative analysis of protease structures from different organisms.

Inhibition of SARS-CoV-2 main protease by allosteric drug-binding

The paper identifies 37 compounds binding to SARS-CoV-2 main protease through X-ray crystallography, with five non-peptidic compounds showing antiviral activity in cell-based assays.

Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease

The paper presents the crystal structure of SARS-CoV-2 main protease covalently bound to a metabolite of HEAT, revealing a pro-drug mechanism and potential for non-peptidic inhibitors.