BiochemistryStructurePeer-reviewed
Deamidation of the human eye lens protein γS-crystallin accelerates oxidative aging
B. Norton-Baker, P. Mehrabi, A. O. Kwok…·R. W. Martin
This study reports six crystal structures of deamidated γS-crystallin variants, showing increased instability, aggregation, and disulfide bond formation, suggesting deamidation accelerates oxidative aging in the human lens.
DOI 10.1016/j.str.2022.03.002