Isogenic sets of hiPSC-CMs harboring KCNH2 mutations capture location-related phenotypic differences
K. O. Brandao, L. van den Brink, D. C. Miller, C. Grandela, B. J. van Meer, M. Mol, L. G. J. Tertoolen, C. L. Mummery, L. Sala, A. O. Verkerk, R. P. Davis
The paper uses hiPSC-CMs with KCNH2 mutations to show phenotypic differences based on mutation location, supporting their use in risk stratification for LQT2.
Stem Cell Reports · Nov 1, 2020Peer-reviewedCell Biology