Author

C. Grandela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

C. L. Mummery· 4 shared B. J. van Meer· 3 shared K. O. Brandao· 3 shared M. P. H. Mol· 3 shared R. P. Davis· 3 shared A. O. Verkerk· 2 shared L. G. J. Tertoolen· 2 shared L. Sala· 2 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCell Biology

C. L. Mummery

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Author profile →

4 papers

Recent·Most cited

STRAIGHT-IN: A platform for high-throughput targeting of large DNA payloads into human pluripotent stem cells

C. Grandela, A. Blanch-Asensio, K. O. Brandao, T. de Korte, L. Yiangou, M. P. H. Mol, B. J. van Meer, C. L. Mummery, R. P. Davis

STRAIGHT-IN enables high-throughput insertion of large DNA payloads into hiPSCs by combining recombinases and CRISPR/Cas9 for precise genomic editing.

bioRxiv · Dec 8, 2021Cell Biology

Isogenic sets of hiPSC-CMs harboring KCNH2 mutations capture location-related phenotypic differences

K. O. Brandao, L. van den Brink, D. C. Miller, C. Grandela, B. J. van Meer, M. Mol, L. G. J. Tertoolen, C. L. Mummery, L. Sala, A. O. Verkerk, R. P. Davis

The paper uses hiPSC-CMs with KCNH2 mutations to show phenotypic differences based on mutation location, supporting their use in risk stratification for LQT2.

Stem Cell Reports · Nov 1, 2020Peer-reviewedCell Biology

Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties

L. van den Brink, K. O. Brandao, C. Grandela, M. P. H. Mol, C. L. Mummery, A. O. Verkerk, R. P. Davis

This study shows cryopreservation does not harm the molecular and functional properties of hiPSC-CMs, though it may enrich ventricular myocytes.

bioRxiv · Jul 14, 2019Cell Biology

Versatile open software to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

L. Sala, B. J. van Meer, L. G. J. Tertoolen, J. Bakkers, M. Bellin, R. Davis, C. Denning, M. A. E. Dieben, T. Eschenhagen, E. Giacomelli, C. Grandela, A. Hansen, E. R. Holman, M. R. M. Jongbloed, S. M. Kamel, , F. L. Burton

MUSCLEMOTION quantifies cardiac contraction in vitro and in vivo, providing reliable pharmacological and disease phenotype data across multiple models.

bioRxiv · Jul 8, 2017Physiology