Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism
Q. Liu, A. Gupta, A. Okesli-Armlovich, W. Qiao, C. Fischer, M. Smith, J. E. Carette, M. C. Bassik, C. Khosla
The paper identifies DHODH as a target of GSK983 and shows that combining it with pyrimidine salvage inhibitors like CPU enhances antiviral efficacy against dengue virus.
bioRxiv · Mar 24, 2020Biochemistry