Author

A. P. Browning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 6 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:imaging· 3 Research Focus:differential expression· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

M. J. Simpson· 7 shared G. Gunasingh· 3 shared N. K. Haass· 3 shared R. J. Murphy· 3 shared M. J. Plank· 2 shared A. L. Jenner· 1 shared A. P. Johnston· 1 shared B. Lawson· 1 shared

Activity by Year

2017-2021 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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7 shared papersBiophysics

M. J. Simpson

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Author profile →

7 papers

Recent·Most cited

A stochastic mathematical model of 4D tumour spheroids with real-time fluorescent cell cycle labelling

J. J. Klowss, A. P. Browning, R. J. Murphy, E. J. Carr, M. J. Plank, G. Gunasingh, N. K. Haass, M. J. Simpson

This paper develops a stochastic individual-based model of 4D tumour spheroids and validates it against experimental data from human melanoma cell line experiments.

bioRxiv · Nov 28, 2021Biophysics

Identifying cell-to-cell variability in internalisation using flow cytometry

A. P. Browning, N. Ansari, C. Drovandi, A. P. Johnston, M. J. Simpson, A. L. Jenner

The paper develops a mathematical model to quantify cell-to-cell variability in internalisation using flow cytometry data from human B-cell lymphoblastoid cells.

bioRxiv · Nov 24, 2021 · PreprintCell Biology

Designing and interpreting 4D tumour spheroid experiments

R. J. Murphy, A. P. Browning, G. Gunasingh, N. K. Haass, M. J. Simpson

This study evaluates 4D tumour spheroid experiments by comparing designs and identifying reliable insights using mathematical modeling and statistical analysis.

bioRxiv · Aug 18, 2021Biophysics

Quantitative analysis of tumour spheroid structure

A. P. Browning, J. A. Sharp, R. J. Murphy, G. Gunasingh, B. Lawson, K. Burrage, N. K. Haass, M. J. Simpson

This study quantifies tumour spheroid structure, showing that limiting structure is independent of initial seeding density and spheroid size.

bioRxiv · Aug 5, 2021Cancer Biology

Model-based data analysis of tissue growth in thin 3D printed scaffolds

A. P. Browning, O. J. Maclaren, P. R. Buenzli, M. Lanaro, M. C. Allenby, M. A. Woodruff, M. J. Simpson

The paper analyzes tissue growth in 3D printed scaffolds using a mathematical model to quantify cell proliferation and migration, identifying two growth stages and model limitations.

bioRxiv · Mar 25, 2021Cell Biology

Identifying density-dependent interactions in collective cell behaviour

A. P. Browning, W. Jin, M. J. Plank, M. J. Simpson

The paper develops an individual-based model to study density-dependent cell behavior in scratch assays, finding that motility depends on cell density but proliferation does not.

bioRxiv · Feb 28, 2020Cell Biology

A Bayesian computational approach to explore the optimal duration of a cell proliferation assay

A. P. Browning, S. McCue, M. J. Simpson

The paper uses Bayesian methods to assess how assay duration affects the detection of crowding effects in cell proliferation models.

bioRxiv · Jun 9, 2017Biophysics