N. K. Haass

Formation and growth of co-culture tumour spheroids: new compartment-based mathematical models and experiments

This paper develops new compartment-based mathematical models and analyzes experimental data to better understand co-culture tumour spheroid formation and growth.

Persister state-directed transitioning and vulnerability in melanoma

This study identifies a compound that induces a persister state in melanoma cells, promoting differentiation and sensitizing them to a prodrug, offering a dual-target strategy for treatment.

Growth and adaptation mechanisms of tumour spheroids with time-dependent oxygen availability

This study investigates how time-dependent oxygen availability affects tumour spheroid growth and identifies new adaptation mechanisms.

Compression-dependent microtubule reinforcement comprises a mechanostat which enables cells to navigate confined environments

The paper shows that microtubules form a mechanostat to coordinate contractility and nuclear positioning during confined cell migration.

A stochastic mathematical model of 4D tumour spheroids with real-time fluorescent cell cycle labelling

This paper develops a stochastic individual-based model of 4D tumour spheroids and validates it against experimental data from human melanoma cell line experiments.

Designing and interpreting 4D tumour spheroid experiments

This study evaluates 4D tumour spheroid experiments by comparing designs and identifying reliable insights using mathematical modeling and statistical analysis.

Quantitative analysis of tumour spheroid structure

This study quantifies tumour spheroid structure, showing that limiting structure is independent of initial seeding density and spheroid size.

Mathematical model of tumour spheroid experiments with real-time cell cycle imaging

This paper develops a mathematical model to interpret FUCCI-labelled tumour spheroid growth experiments, capturing cell cycle dynamics and drug responses.

Phenotypic melanoma heterogeneity is regulated through cell-matrix interaction-dependent changes in tumor microarchitecture

This paper shows that melanoma phenotypic heterogeneity is controlled by cell-ECM crosstalk, altering tumor microarchitecture and mechanotransduction.

Synchronised oscillations in growing cell populations are explained by demographic noise

This study shows that synchronized oscillations in growing cell populations arise from demographic noise rather than active cell-cell communication.

Examining go-or-grow using fluorescent cell-cycle indicators and cell cycle-inhibiting drugs

This study examines the go-or-grow hypothesis in melanoma cells using fluorescent cell-cycle indicators and drugs, finding no support for the hypothesis as motility is independent of cell-cycle phase.

Abrogation of RAB27A expression transiently affects melanoma cell proliferation

This study shows that RAB27A knockdown temporarily reduces melanoma cell proliferation but has a lasting effect on invasion and metastasis.