J. C. Santos

Deep Divergences Among Inconspicuously Colored Clades of Epipedobates Poison Frogs

The paper identifies deep genetic divergences and two new species within inconspicuously colored Epipedobates poison frogs, clarifying taxonomy and geographic distribution.

Selection on visual opsin genes in diurnal Neotropical frogs and loss of the SWS2 opsin in poison frogs

The paper identifies positive selection on opsin genes in diurnal Neotropical frogs and reports the loss of SWS2 opsin in poison frogs, suggesting implications for their visual adaptation and chemical ecology.

GPR183 mediates the capacity of the novel CD47-CD19 bispecific antibody TG-1801 to heighten ublituximab-umbralisib (U2) anti-lymphoma activity

This study shows that TG-1801 enhances ublituximab's anti-lymphoma activity through GPR183-mediated mechanisms in B-NHL models.

Optogenetic activators of apoptosis, necroptosis and pyroptosis for probing cell death dynamics and bystander cell responses

This paper develops optoCDEs, optogenetic tools to induce apoptosis, pyroptosis, and necroptosis, and uses them to study bystander cell responses to different cell death types.

The AIRE G228W mutation disturbs the interaction of AIRE with its partner molecule SIRT1

This study investigates how the AIRE G228W mutation disrupts the AIRE-SIRT1 interaction, affecting transcriptional processes in medullary thymic epithelial cells.

Much more than a clasp: Evolutionary pattern of amplexus diversity in anurans

The paper reconstructs the evolutionary history of amplexus in anurans, finding 35 transitions and high phylogenetic conservation, with no link to sexual size dimorphism.

Type-3 Secretion System-induced pyroptosis protects Pseudomonas against cell-autonomous immunity

This study shows that Pseudomonas aeruginosa uses its Type-3 Secretion System to induce macrophage pyroptosis, escaping immune trapping, while T3SS-deficient strains are captured by inflammasome-mediated immunity.