ARS2-directed alternative splicing mediates CD28 driven T cell glycolysis and effector function
G. A. Holling, A. P. Sharda, M. M. Honikel, C. M. James, S. M. Lightman, G. Qiao, K. L. Singel, T. R. Emmons, T. Giridharan, S. Hou, A. M. Intlekofer, R. M. Higashi, T. W. M. Fan, A. N. Lane, K. H. Eng, , S. H. Olejniczak
This study shows ARS2 promotes CD28-driven T cell glycolysis and effector function through alternative splicing of Pkm2, enhancing anti-tumor immunity.
bioRxiv · May 7, 2021 · PreprintImmunology