Author

A. M. Intlekofer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

E. Reznik· 2 shared S. Hou· 2 shared A. A. Hakimi· 1 shared A. H. Shih· 1 shared A. Kentsis· 1 shared A. N. Lane· 1 shared A. P. Sharda· 1 shared A. Tosolini· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

E. Reznik

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Co-regulation

E. Benedetti, E. M. Liu, C. Tang, F. Kuo, M. Buyukozkan, T. Park, J. Park, F. Correa, A. A. Hakimi, A. M. Intlekofer, J. Krumsiek, E. Reznik

The paper constructs a multimodal tumor metabolism atlas to identify gene-metabolite co-regulation patterns across cancer types.

bioRxiv · Nov 23, 2022 · PreprintCancer Biology

ARS2-directed alternative splicing mediates CD28 driven T cell glycolysis and effector function

G. A. Holling, A. P. Sharda, M. M. Honikel, C. M. James, S. M. Lightman, G. Qiao, K. L. Singel, T. R. Emmons, T. Giridharan, S. Hou, A. M. Intlekofer, R. M. Higashi, T. W. M. Fan, A. N. Lane, K. H. Eng, , S. H. Olejniczak

This study shows ARS2 promotes CD28-driven T cell glycolysis and effector function through alternative splicing of Pkm2, enhancing anti-tumor immunity.

bioRxiv · May 7, 2021 · PreprintImmunology

Discovery of protein modifications using high resolution differential mass spectrometry proteomics

P. Cifani, Z. Li, D. Luo, M. Grivainis, A. M. Intlekofer, D. Fenyo, A. Kentsis

This paper introduces SAMPEI, a spectral alignment method for detecting protein modifications using high-resolution mass spectrometry, demonstrating its effectiveness in identifying sub-stoichiometric modifications in mouse macrophages.

bioRxiv · Jun 19, 2020Biochemistry

Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition

J. J. Harding, M. A. Lowery, A. H. Shih, J. M. Schvartzman, S. Hou, C. Famulare, M. Patel, M. Roshal, R. K. G. Do, A. Zehir, D. You, S. D. Selcuklu, A. Viale, M. S. Tallman, D. M. Hyman, , A. M. Intlekofer

The paper identifies isoform switching between mutant IDH1 and IDH2 as a mechanism of acquired resistance to IDH inhibitors in cancers.

bioRxiv · Aug 1, 2018Cancer Biology