K. H. Eng

Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence

Stromal resistance to castration-induced prostate regression in a mouse model of benign prostatic hyperplasia

This study shows that stromal compartments in a mouse model of BPH are resistant to castration-induced regression, suggesting the need for additional therapies.

Glucocorticoid signaling delays castration-induced regression in murine models of prostate cancer

This study shows that glucocorticoid signaling delays castration-induced regression in murine prostate cancer models by maintaining tumor proliferation through GR activation, which can be blocked by the GR antagonist relacorilant.

ARS2-directed alternative splicing mediates CD28 driven T cell glycolysis and effector function

This study shows ARS2 promotes CD28-driven T cell glycolysis and effector function through alternative splicing of Pkm2, enhancing anti-tumor immunity.

Patient derived models of bladder cancer amplify tumor specific gene expression compared to surgical specimen while maintaining gene expression of molecular subtype and epithelial mesenchymal transition markers

This study compares gene expression profiles of patient-derived models (PDMs) with surgical specimens of bladder cancer, finding PDXs most similar to original tumors while maintaining EMT and molecular subtype markers.

Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma

This study identifies APA-driven gene expression changes in pancreatic ductal adenocarcinoma, revealing miRNA loss and therapeutic targets like CK1.