A rugged yet easily navigable fitness landscape of antibiotic resistance
A. Papkou, L. Garcia-Pastor, J. A. Escudero, A. Wagner
The paper maps the fitness landscape of E. coli DHFR mutants under trimethoprim and finds that while rugged, high fitness peaks are accessible and have large basins of attraction.
bioRxiv · Feb 27, 2023 · PreprintEvolutionary Biology