Author

L. Garcia-Pastor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

J. A. Escudero· 4 shared E. Vergara· 3 shared F. Trigo da Roza· 3 shared A. Hipolito· 2 shared A. San Millan· 2 shared L. Toribio-Celestino· 2 shared P. Blanco· 2 shared A. Buendia· 1 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersMicrobiology

J. A. Escudero

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The expression of integron arrays is shaped by the translation rate of cassettes

A. Carvalho, A. Hipolito, F. Trigo da Roza, L. Garcia-Pastor, E. Vergara, A. Buendia, T. Garcia-Seco, J. A. Escudero

The paper shows that integron cassette expression depends on upstream translation rates, not distance to the Pc promoter.

bioRxiv · Mar 26, 2024Microbiology

IDENTIFICATION OF PROMOTER ACTIVITY IN GENE-LESS CASSETTES FROM VIBRIONACEAE SUPERINTEGRONS

P. Blanco, A. Hipolito, L. Garcia-Pastor, F. Trigo da Roza, L. Toribio-Celestino, A. C. Ortega, E. Vergara, A. San Millan, J. A. Escudero

The paper identifies promoter activity in gene-less cassettes from Vibrio superintegrons, showing they enhance downstream cassette expression and confer antibiotic resistance.

bioRxiv · Nov 21, 2023 · PreprintMicrobiology

Chromosomal Integrons are Genetically and Functionally Isolated Units of Genomes

P. Blanco, F. Trigo da Roza, L. Toribio-Celestino, L. Garcia-Pastor, N. Caselli, F. Ojeda, B. Darracq, E. Vergara, A. San Millan, O. Skovgaard, D. Mazel, C. Loot, J. A. Escudero

The paper deletes a chromosomal integron in Vibrio cholerae and shows it has no detectable effect on physiology, proving its genetic and functional isolation.

bioRxiv · Nov 17, 2023Microbiology

A rugged yet easily navigable fitness landscape of antibiotic resistance

A. Papkou, L. Garcia-Pastor, J. A. Escudero, A. Wagner

The paper maps the fitness landscape of E. coli DHFR mutants under trimethoprim and finds that while rugged, high fitness peaks are accessible and have large basins of attraction.

bioRxiv · Feb 27, 2023 · PreprintEvolutionary Biology